Or a guy named Caesar and his wannabe roman empire that happens to control most of Southwest USA. Or a billionaire who survived the nuclear war and owns Vegas currently. The craziest thing about this game is that there is no main villain after the first act. Your decisions genuinely matter in this game, and some might even come to help you out in the final quest.
The amount of branching sidequests with different endings is massive, and what's crazy is how the vast majority of them play into the ending for the faction they represent that you'll get. From the moment Benny put two bullets in your head in the intro cutscene to the Battle of Hoover Dam, I was hooked from minute 1. Yet it's also a great game as a standalone, you don't need to know all of these things to appreciate it. It feels like a sequel to the originals with the amount of returning characters, factions, and easter eggs and references. The power of Doc Mitchell's spinning head and crashes, I guess. Interestingly enough this game did not get good reception when it dropped.